Description

(S)-2-Hydroxymethyl-Piperazine-2Hcl is a high-purity chiral piperazine derivative, specifically the hydrochloride salt of the (S)-enantiomer. This compound is a critical chiral building block and intermediate in the synthesis of active pharmaceutical ingredients (APIs), where stereochemical purity is paramount. It is essential for research and production in the pharmaceutical, agrochemical, and fine chemical industries, particularly for developing enantiomerically pure drugs and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of enantiomerically pure APIs, including antiviral agents, central nervous system (CNS) drugs, and enzyme inhibitors.
• Asymmetric Catalyst Ligand Precursor: Used to develop and synthesize novel chiral ligands for asymmetric catalysis in fine chemical manufacturing.
• Agrochemical Research: Serves as a building block for creating chiral active ingredients in herbicides, fungicides, and pesticides with improved efficacy and selectivity.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes, enzyme substrates, and inhibitors for biochemical research.
• Custom Synthesis & Process Development: Utilized by contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects and route scouting.
• Academic & Industrial R&D: A valuable reagent for medicinal chemistry programs and novel synthetic methodology development in university and corporate laboratories.

Basic Information

Product Name	(S)-2-Hydroxymethyl-Piperazine-2Hcl
CAS No.	149629-73-2
Molecular Formula	C5H12N2O • 2HCl
Molecular Weight	209.09 g/mol
Synonyms	(S)-2-(Hydroxymethyl)piperazine dihydrochloride; (S)-Piperazine-2-methanol dihydrochloride; (2S)-2-Piperazinemethanol dihydrochloride; (S)-2-Hydroxymethylpiperazine dihydrochloride; (S)-2-Piperazinemethanol dihydrochloride; (S)-2-Methanolpiperazine dihydrochloride; (S)-2-HMP • 2HCl
EINECS	Contact for details

Quality Control

Our (S)-2-Hydroxymethyl-Piperazine-2Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and chiral purity, meeting the stringent requirements for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, impurity profile, and chiral excess is provided with every shipment to ensure traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.