Description

m-Peg2-Acid is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a carboxylic acid group at one terminus and a methoxy group at the other. This compound is a critical building block in bioconjugation and pharmaceutical development, enabling the precise modification of biomolecules to enhance their solubility, stability, and pharmacokinetic properties. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require reliable, well-characterized linkers for creating PEGylated therapeutics, diagnostic agents, and functionalized surfaces.

Application

• Bioconjugation and PEGylation: A key reagent for attaching therapeutic proteins, peptides, and antibodies to PEG chains to improve circulation half-life and reduce immunogenicity.
• Drug Delivery Systems: Used as a functional spacer or linker in the synthesis of polymer-drug conjugates, micelles, and nanoparticles for targeted delivery.
• Diagnostic Reagents: Facilitates the labeling of biomarkers, antibodies, and other probes with fluorescent dyes or other detection moieties for assay development.
• Surface Functionalization: Employed to modify surfaces (e.g., nanoparticles, chips, sensors) with carboxylic acid groups for subsequent covalent immobilization of biomolecules.
• Crosslinking Agent: Serves as a hydrophilic, flexible crosslinker in hydrogel formation and polymer chemistry.
• Intermediate Synthesis: Acts as a versatile precursor for synthesizing more complex PEG derivatives with active esters, amines, or other functional groups.

Basic Information

Product Name	m-Peg2-Acid
CAS No.	149577-05-9
Molecular Formula	C9H18O6
Molecular Weight	222.24 g/mol
Synonyms	mPEG2-acid; Methoxy-PEG2-acid; 2-[2-(2-Methoxyethoxy)ethoxy]acetic acid; 3,6,9-Trioxaundecanoic acid, 11-methoxy-; mPEG2-COOH; O-(2-Methoxyethyl)-O'-(carboxymethyl)diethylene glycol; Carboxymethyl-PEG2-methyl ether; Acetic acid, 2-[2-(2-methoxyethoxy)ethoxy]-
EINECS	Contact for details

Quality Control

Our m-Peg2-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and titration for acid content, to ensure it meets the high standards required for pharmaceutical and biotech applications. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability, consistency, and compliance with your research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Acid Value (Titration)	247 - 257 mg KOH/g
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.