Description

S-Sulindac Sulfoxide is a specific stereoisomer of sulindac sulfoxide, a key intermediate in the synthesis of the non-steroidal anti-inflammatory drug (NSAID) Sulindac. This high-purity chiral building block is critical for ensuring the efficacy and safety profile of the final active pharmaceutical ingredient (API). It is primarily required by pharmaceutical R&D laboratories, process chemists, and manufacturers engaged in the development and production of enantiomerically pure therapeutics.

Application

• Pharmaceutical Intermediate: Primary use as a chiral synthon in the synthesis of the NSAID Sulindac (S-isomer).
• Process Chemistry & R&D: Serves as a critical reference standard and starting material for route scouting and process optimization in API manufacturing.
• Analytical Standard: Used as a high-purity standard for method development and validation in quality control (QC) laboratories for Sulindac analysis.
• Chiral Chemistry Studies: Valuable compound for research in stereoselective synthesis and chiral resolution techniques.
• Regulatory Filings: Essential material for generating impurity profiles and supporting documentation for drug master files (DMFs) and regulatory submissions.

Basic Information

Product Name	S-Sulindac Sulfoxide
CAS No.	149116-77-8
Molecular Formula	C20H17FO3S
Molecular Weight	356.41 g/mol
Synonyms	(Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid, (S)-Isomer; (S)-Sulindac Sulfoxide; Sulindac (S)-Sulfoxide; (Z)-Sulindac S-Sulfoxide; FGN-1 (Sulfoxide); MK-231 (Sulfoxide, S-form)
EINECS	Contact for details

Quality Control

Our S-Sulindac Sulfoxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay and impurity profiling by HPLC, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (S-Isomer)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.