Description

n-1-Boc-n-4-Cbz-2-Piperazine Carboxylic Acid is a high-purity, bifunctional protected piperazine derivative, serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in enabling the controlled, sequential introduction of different functional groups onto the piperazine scaffold, which is a privileged structure in medicinal chemistry. This compound is essential for research and development chemists in the pharmaceutical and biotechnology sectors who are synthesizing novel drug candidates, particularly for central nervous system (CNS) disorders, oncology, and infectious diseases.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of complex active pharmaceutical ingredients (APIs) and investigational new drugs.
• Peptidomimetic Chemistry: Used in constructing constrained peptide analogs and macrocyclic compounds by providing a rigid, functionalized piperazine core.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Employed in the development of tool compounds and molecular probes for target validation and mechanistic studies.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis organizations (CSOs) and CDMOs producing bespoke compounds for client projects.
• Academic Research: Used in university and institutional labs for methodological development in heterocyclic and synthetic organic chemistry.

Basic Information

Product Name	n-1-Boc-n-4-Cbz-2-Piperazine Carboxylic Acid
CAS No.	149057-19-2
Molecular Formula	C18H24N2O6
Molecular Weight	364.40 g/mol
Synonyms	1-Boc-4-Cbz-2-piperazinecarboxylic acid; 1-(tert-Butoxycarbonyl)-4-(benzyloxycarbonyl)piperazine-2-carboxylic acid; (2S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-4-(phenylmethoxycarbonyl)piperazine-2-carboxylic acid; 2-Piperazinecarboxylic acid, 1,4-bis[(1,1-dimethylethoxy)carbonyl]-, (S)-; Boc-Cbz-piperazine-2-COOH; (S)-1-Boc-4-Cbz-piperazine-2-carboxylic acid; tert-Butyl 4-(benzyloxycarbonyl)-2-carboxypiperazine-1-carboxylate; N-Boc-N'-Cbz-L-piperazine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our n-1-Boc-n-4-Cbz-2-Piperazine Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing purity, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.