Description

9-Dihydrotaxol is a key taxane derivative and a significant intermediate in the synthesis of the potent anticancer drug Paclitaxel. This compound is essential for pharmaceutical research and development, offering a critical building block for creating novel chemotherapeutic agents and exploring structure-activity relationships. It is primarily utilized by pharmaceutical manufacturers, biotechnology research firms, and academic institutions engaged in oncology drug discovery and advanced organic synthesis.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of Paclitaxel (Taxol®) and related taxane-based anticancer drugs.
• Oncology Research: Used as a reference standard and active compound in biochemical and pharmacological studies to investigate mechanisms of tubulin stabilization and apoptosis.
• Medicinal Chemistry: Serves as a core scaffold for the semi-synthetic development of new taxane analogs with potentially improved efficacy or reduced side effects.
• Process Development: Employed in scaling up and optimizing manufacturing processes for taxane-based active pharmaceutical ingredients (APIs).
• Analytical Standard: Provides a high-purity standard for quality control (QC) and analytical method development (e.g., HPLC, LC-MS) in pharmaceutical production.

Basic Information

Product Name	9-Dihydrotaxol
CAS No.	148584-53-6
Molecular Formula	C47H51NO14
Molecular Weight	853.91 g/mol
Synonyms	9-Dihydrotaxol A; 9-Dihydro Taxol; 9-DH-Taxol; 10-Deacetyl-9-dihydrotaxol; NSC 654663; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecah-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate
EINECS	Contact for details

Quality Control

Our 9-Dihydrotaxol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C to maximize stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0% Any single unknown impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.