Description

α-Galactosyl-C18-Ceramide is a synthetic glycosphingolipid, specifically a galactose-modified ceramide derivative. This compound is of significant interest in immunological research as a potent antigen for invariant Natural Killer T (iNKT) cells. It is primarily utilized by research institutions and pharmaceutical companies for studying immune modulation, glycolipid biology, and developing novel therapeutic strategies. The product is supplied as a high-purity reference standard for critical laboratory applications.

Application

• Immunological Research: As a model antigen for stimulating and studying invariant Natural Killer T (iNKT) cell responses.
• Drug Discovery: A key tool in the development of immunomodulators and vaccine adjuvants targeting the CD1d pathway.
• Biochemical Standard: Used as a reference compound in analytical methods like HPLC and mass spectrometry for glycolipid quantification.
• Cell Signaling Studies: Investigating the role of glycosphingolipids in cellular communication and immune system regulation.
• Academic Research: Fundamental studies in glycolipid chemistry, membrane biology, and antigen presentation mechanisms.

Basic Information

Product Name	α-Galactosyl-C18-Ceramide
CAS No.	148347-40-4
Molecular Formula	C46H89NO9
Molecular Weight	800.20 g/mol
Synonyms	α-Galactosylceramide; α-GalCer; KRN7000; (2S,3S,4R)-1-O-(α-D-Galactopyranosyl)-2-(N-octadecanoylamino)-1,3,4-octadecanetriol; Galα1-Cer; C18:0 α-Galactosylceramide; iNKT cell antigen; Synthetic Glycosphingolipid
EINECS	Contact for details

Quality Control

Our α-Galactosyl-C18-Ceramide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The product is moisture-sensitive; keep the container tightly sealed in a dry environment. Allow the vial to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.