Description

1-(2,3-Dihydro-Benzo[1,4]Dioxin-6-Yl)-Piperazine is a versatile heterocyclic compound featuring a benzodioxane core linked to a piperazine moiety, making it a valuable building block in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and other high-value specialty chemicals. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and material science industries seeking to create novel molecules with specific biological or physical properties.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of central nervous system (CNS) active compounds, potential antipsychotics, and other therapeutic agents.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its heterocyclic structure for bioactivity.
• Ligand and Catalyst Development: Serves as a scaffold for creating complex ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science: Employed in the synthesis of specialty polymers and organic electronic materials due to its rigid, fused-ring structure.
• Chemical Biology Probe Synthesis: Utilized as a building block for creating molecular probes to study biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	1-(2,3-Dihydro-Benzo[1,4]Dioxin-6-Yl)-Piperazine
CAS No.	148245-18-5
Molecular Formula	C12H16N2O2
Molecular Weight	220.27 g/mol
Synonyms	6-(1-Piperazinyl)-2,3-dihydro-1,4-benzodioxine; 1-(2,3-Dihydro-1,4-benzodioxin-6-yl)piperazine; 6-Piperazino-1,4-benzodioxane; 1,4-Benzodioxan-6-yl-piperazine; 2,3-Dihydro-1,4-benzodioxin-6-yl-piperazine; 6-(Piperazin-1-yl)-2,3-dihydrobenzo[b][1,4]dioxine; 148245-18-5; 1-(1,4-Benzodioxan-6-yl)piperazine
EINECS	Contact for details

Quality Control

Our 1-(2,3-Dihydro-Benzo[1,4]Dioxin-6-Yl)-Piperazine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.