Description

Luffariolide G CAS NO 147663-79-4 is a bioactive marine natural product belonging to the class of sesterterpenoids. This compound is of significant interest for its potent biological activity, particularly as a selective inhibitor of human group V secreted phospholipase A2 (GV sPLA2). It serves as a critical research tool and a promising lead compound for the development of novel anti-inflammatory and therapeutic agents. Key industries requiring this high-purity biochemical include pharmaceutical R&D, biotechnology, and academic research institutions focused on inflammation pathways and drug discovery.

Application

• Pharmaceutical Research & Development: As a selective inhibitor for mechanistic studies of the GV sPLA2 enzyme and its role in inflammatory diseases.
• Lead Compound Optimization: Serving as a structural template for the medicinal chemistry synthesis of novel anti-inflammatory drug candidates.
• Biochemical Assay Standard: Use as a reference standard in high-throughput screening (HTS) campaigns and in vitro enzymatic assays.
• Academic & Preclinical Studies: Investigating signaling pathways in cellular models of inflammation, asthma, and atherosclerosis.
• Specialty Chemical Synthesis: As a key intermediate or target molecule for the synthesis of complex natural product analogs.

Basic Information

Product Name	Luffariolide G
CAS No.	147663-79-4
Molecular Formula	C₂₅H₃₈O₄
Molecular Weight	402.57 g/mol
Synonyms	(12E,20Z)-11,12-Seco-13,14-didehydro-12,20-cyclo-12-nor-9,11-dideoxy-9,11-didehydrogorgosterol; 12,20-Cyclo-13,14-didehydro-11,12-seco-12-nor-9,11-dideoxy-9,11-didehydrogorgosterol, (12E,20Z)-; Luffariellolide G; GV sPLA2 Inhibitor (Luffariolide G); Marine Sesterterpenoid.
EINECS	Contact for details

Quality Control

Every batch of Luffariolide G is produced and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and identification results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (by NMR)
Water Content	≤ 1.0% (KF)
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.