Description

Calcipotriol Monohydrate is a synthetic vitamin D3 analog widely recognized for its potent regulatory effects on skin cell growth and differentiation. This high-purity active pharmaceutical ingredient is critical for developing targeted topical therapies for chronic skin conditions. It is primarily utilized by pharmaceutical manufacturers and research institutions in the dermatology sector for the formulation of advanced prescription medications.

Application

• Active Pharmaceutical Ingredient (API) in topical ointments, creams, and lotions for psoriasis treatment.
• Key component in combination therapies, often formulated with corticosteroids for enhanced efficacy.
• Research chemical for studying vitamin D receptor (VDR) pathways and cell proliferation mechanisms.
• Reference standard in analytical laboratories for quality control and method development.
• Starting material for the synthesis of novel vitamin D analogs in pharmaceutical R&D.

Basic Information

Product Name	Calcipotriol Monohydrate
CAS No.	147657-22-5
Molecular Formula	C27H40O3 • H2O
Molecular Weight	430.61 g/mol
Synonyms	Calcipotriene Monohydrate; MC 903; (5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1α,3β,24-triol Monohydrate; Daivonex (trade name); Dovonex (trade name); Psorcutan (trade name); Vitamin D3 Analog
EINECS	Contact for details

Quality Control

Our Calcipotriol Monohydrate is manufactured under strict quality management systems. Each batch is tested to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A comprehensive Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and microbiological limits is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	3.5% - 4.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Microbiological Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.