Description

1H-1,4,7-Triazonine-1,4,7-Triacetic Acid, 2-[(4-Aminophenyl)Methyl]Hexahydro- is a specialized bifunctional chelating agent that serves as a critical intermediate in the synthesis of advanced diagnostic and therapeutic agents. Its core value lies in its ability to form stable, inert complexes with various metal ions, particularly radiometals, enabling targeted delivery in biomedical applications. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing next-generation radiopharmaceuticals, MRI contrast agents, and targeted cancer therapies.

Application

• Radiopharmaceutical Precursor: Key intermediate for synthesizing chelator-conjugated biomolecules (antibodies, peptides) for diagnostic imaging (PET, SPECT) and targeted radionuclide therapy.
• Contrast Agent Development: Building block for creating gadolinium(III) or other lanthanide-based complexes used as contrast enhancers in Magnetic Resonance Imaging (MRI).
• Bifunctional Chelator (BFC): Used to attach radioisotopes (e.g., 68Ga, 177Lu, 90Y, 64Cu) to targeting vectors while maintaining complex stability in vivo.
• Theranostic Agent Synthesis: Enables the development of paired diagnostic and therapeutic (theranostic) agents using the same chelator platform with different isotopes.
• Research Chemical: Used in academic and industrial R&D for studying metal-ligand coordination chemistry, pharmacokinetics, and novel drug delivery systems.
• Chemical Biology Tool: Facilitates the labeling and tracking of biomolecules in cellular and molecular biology research.

Basic Information

Item	Details
Product Name	1H-1,4,7-Triazonine-1,4,7-Triacetic Acid, 2-[(4-Aminophenyl)Methyl]Hexahydro-
CAS No.	147597-65-7
Molecular Formula	C17H26N4O6
Molecular Weight	382.41 g/mol
Synonyms	2-[(4-Aminobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid; 2-(4-Aminobenzyl)-NOTA; 4-Aminobenzyl-NOTA; p-Aminobenzyl-NOTA; AB-NOTA; NOTA-Bn-NH2; 1,4,7-Triazacyclononane-N,N',N''-triacetic acid, 2-[(4-aminophenyl)methyl] derivative; 2-(4-Aminobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid
EINECS	Contact for details

Quality Control

Our 1H-1,4,7-Triazonine-1,4,7-Triacetic Acid, 2-[(4-Aminophenyl)Methyl]Hexahydro- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, identity, and consistency, meeting the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing purity (by HPLC), identity (by 1H NMR, MS), and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.