Description

1,2-Dioleoyl-Glycero-3-Phospho-5'-(2',3')-Dideoxycytidine is a specialized, high-purity phospholipid-nucleoside conjugate, a critical building block in advanced pharmaceutical and biotechnology research. This compound matters for its role as a key intermediate in the synthesis of novel lipid-based drug delivery systems, particularly for nucleic acid therapeutics. Researchers and manufacturers in the fields of liposome formulation, mRNA vaccine development, and targeted cancer therapy require this precise chemical to develop next-generation treatments with improved efficacy and stability.

Application

• Lipid Nanoparticle (LNP) Formulation: A critical synthetic precursor for constructing ionizable or cationic lipids used in mRNA and siRNA delivery systems.
• Prodrug Development: Serves as a lipophilic prodrug moiety to enhance the cellular uptake and bioavailability of nucleoside analogs.
• Phospholipid Research: Used as a model compound in studies investigating membrane biophysics, lipid metabolism, and the behavior of functionalized lipids.
• Targeted Drug Delivery: Incorporated into ligand-targeted liposomes for the site-specific delivery of chemotherapeutic agents.
• Diagnostic Agent Synthesis: Acts as a starting material for creating lipid-conjugated imaging probes or contrast agents.
• Antiviral Research: Investigated for its potential as a component in lipid-based formulations of antiviral nucleoside drugs.

Basic Information

Item	Detail
Product Name	1,2-Dioleoyl-Glycero-3-Phospho-5'-(2',3')-Dideoxycytidine
CAS No.	147556-77-2
Molecular Formula	C48H86N3O11P
Molecular Weight	888.19 g/mol
Synonyms	DODC; 1,2-Dioleoyl-sn-glycero-3-phospho-2',3'-dideoxycytidine; 2',3'-Dideoxycytidine 5'-(1,2-di-9Z-octadecenoyl-sn-glycero-3-phosphate); Dideoxycytidine diphosphate diacylglycerol; Lipid-conjugated ddC; 5'-O-[1,2-Di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-2',3'-dideoxycytidine; Cytidine phospholipid conjugate
EINECS	Contact for details

Quality Control

Every batch of 1,2-Dioleoyl-Glycero-3-Phospho-5'-(2',3')-Dideoxycytidine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency suitable for research and pharmaceutical development. Certificates of Analysis (COA) with full traceability are provided and can be tailored to meet specific project or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 1.0 %
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.