Description

tert-Butyl Piperazin-1-Ylcarbamate is a high-purity, protected piperazine derivative widely used as a critical building block in advanced organic synthesis. Its primary value lies in providing a versatile and reactive nitrogen-containing scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for API synthesis and novel compound libraries.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry & Drug Discovery: Serves as a versatile scaffold for constructing diverse compound libraries during hit-to-lead optimization and structure-activity relationship (SAR) studies.
• Peptidomimetic Synthesis: Used in the preparation of peptidomimetics and constrained peptide analogs due to its piperazine core, which can mimic peptide backbone structures.
• Agrochemical Research: Employed as an intermediate in the development of novel herbicides, fungicides, and insecticides that incorporate nitrogen heterocycles.
• Ligand and Catalyst Preparation: Useful for synthesizing specialized ligands for metal catalysis or as a component of organocatalysts.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Item	Details
Product Name	tert-Butyl Piperazin-1-Ylcarbamate
CAS No.	147081-80-9
Molecular Formula	C9H19N3O2
Molecular Weight	201.27 g/mol
Synonyms	1-Boc-piperazine; N-Boc-piperazine; tert-Butyl 1-piperazinecarboxylate; 1-(tert-Butoxycarbonyl)piperazine; Piperazine-1-carboxylic acid tert-butyl ester; BOC-Piperazine; N-tert-Butoxycarbonylpiperazine; 1-N-Boc-piperazine
EINECS	Contact for details

Quality Control

Our tert-Butyl Piperazin-1-Ylcarbamate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to confirm identity and purity. Certificates of Analysis (COA) detailing all test results are provided with every shipment. We support development and commercial projects requiring compliance with various pharmacopeial standards (e.g., USP, EP) and can tailor specifications to meet specific customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	86 - 90 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.