Description

(S)-1-Boc-3-Methylpiperazine is a high-purity, chiral piperazine derivative widely used as a critical building block in pharmaceutical synthesis. This compound matters because its stereochemistry and protected amine functionality make it an essential intermediate for developing active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery. Pharmaceutical R&D departments, fine chemical manufacturers, and contract research organizations (CROs) need this material for constructing complex molecular architectures with high enantiomeric purity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially kinase inhibitors and receptor modulators.
• API Development: Used to construct the core piperazine scaffold in active pharmaceutical ingredients (APIs) requiring specific (S)-configuration.
• Peptidomimetics & PROTACs: Serves as a versatile linker or component in the design of peptide mimics and proteolysis-targeting chimeras (PROTACs).
• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions.
• Chemical Biology Probes: Utilized in the development of tool compounds and molecular probes for biological target validation.
• Agrochemical Research: Potential intermediate for creating chiral active ingredients in advanced crop protection agents.

Basic Information

Product Name	(S)-1-Boc-3-Methylpiperazine
CAS No.	147081-29-6
Molecular Formula	C10H20N2O2
Molecular Weight	200.28 g/mol
Synonyms	(S)-1-(tert-Butoxycarbonyl)-3-methylpiperazine; (S)-3-Methyl-1-Boc-piperazine; (S)-N-Boc-3-methylpiperazine; tert-Butyl (S)-3-methylpiperazine-1-carboxylate; (S)-1-Boc-3-methylpiperazine; (S)-1-N-Boc-3-methylpiperazine; (3S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-3-methylpiperazine; (S)-1-(tert-Butyloxycarbonyl)-3-methylpiperazine
EINECS	Contact for details

Quality Control

Our (S)-1-Boc-3-Methylpiperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure high enantiomeric excess (ee) and purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications for identity, purity, and impurities. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and batch-to-batch consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent degradation. For long-term storage, consider storing under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.