Description

Gambierol CAS NO 146763-62-4 is a potent marine-derived polycyclic ether toxin, primarily known for its role as a ciguatoxin analog. This compound is of significant interest in biochemical and pharmacological research due to its highly specific mechanism of action as a voltage-gated sodium channel modulator. It serves as a critical reference standard and research tool for scientists in toxicology, marine biology, and neuroscience, enabling the study of neurotoxic syndromes and the development of detection methods.

Application

• Pharmacological Research: Used as a reference standard to study the mechanism and effects of ciguatera fish poisoning (CFP).
• Neuroscience Studies: A vital tool for investigating the function and modulation of voltage-gated sodium channels in neuronal signaling.
• Toxicology & Safety Testing: Employed in the development and validation of analytical methods (e.g., LC-MS/MS) for the detection of marine toxins in seafood.
• Biochemical Reference Material: Serves as a high-purity calibrant in quantitative analysis for environmental and food safety monitoring programs.
• Academic & Institutional Research: Supports fundamental research in marine natural products chemistry and the biosynthesis of polyether toxins.
• Drug Discovery: Provides a molecular template for structure-activity relationship (SAR) studies aimed at developing new therapeutic agents or antidotes.

Basic Information

Product Name	Gambierol
CAS No.	146763-62-4
Molecular Formula	C₄₃H₆₄O₁₁
Molecular Weight	756.97 g/mol
Synonyms	Gambierol; (2S,4R,6R,8R,10S,12R,14R,16S,18S,20S,22R,24S,26R,28R,30S,32R,34S,36R,38S,40S,42R)-2,4,6,8,10,12,14,16,18,20,22,24,26,28,30,32,34,36,38,40,42-Heneicosaoxapentatetracontane-43,44,45,46,47,48-hexol; Marine Polyether Toxin; Ciguatoxin Congener
EINECS	Contact for details

Quality Control

Every batch of Gambierol is manufactured and handled under strict quality protocols to ensure identity, purity, and stability. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identification, and impurity profiles is provided with each shipment to support your critical research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation. Keep the container tightly sealed and stored in a cool, dry, well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area Percent)
Water Content (KF)	≤ 1.0 %
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.