Description

(R)-4-(Boc-Amino)-6-Methylheptanoic Acid is a high-purity chiral building block featuring a protected amino group and a carboxylic acid functionality. This compound is critical for the synthesis of complex, biologically active molecules where stereochemical integrity is paramount. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of peptide-based therapeutics, enzyme inhibitors, and other advanced drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other peptide mimetics.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce a specific stereocenter with a protected amine, enabling further chain elongation or modification.
• Protease Inhibitor Development: Serves as a core structural component in the research and production of inhibitors targeting various proteolytic enzymes.
• Chemical Biology & Probe Synthesis: Employed in the creation of labeled compounds and molecular probes for studying biological pathways and target engagement.
• Asymmetric Synthesis: Acts as a starting material or intermediate in catalytic asymmetric reactions to construct more complex chiral architectures.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high stereochemical purity.

Basic Information

Product Name	(R)-4-(Boc-Amino)-6-Methylheptanoic Acid
CAS No.	146453-32-9
Molecular Formula	C13H25NO4
Molecular Weight	259.34 g/mol
Synonyms	(R)-4-((tert-Butoxycarbonyl)amino)-6-methylheptanoic acid; (R)-4-(Boc-amino)-6-methylheptanoic acid; Boc-D-Leucine-OH (Note: This is a common but structurally related synonym); (R)-6-Methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]heptanoic acid; (4R)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-6-methylheptanoic acid; tert-Butyl (R)-(5-carboxy-1-methylpentyl)carbamate
EINECS	Contact for details

Quality Control

Our (R)-4-(Boc-Amino)-6-Methylheptanoic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high chiral purity, essential for sensitive pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.