Description

5-[[4-[2-(5-Acetyl-2-Pyridinyl)Ethoxy]Phenyl]Methyl]-2,4Thiazolidinedione CAS NO 146062-45-5 is a high-purity, non-racemic synthetic intermediate of significant pharmaceutical importance. This compound serves as a critical building block in the research and development of novel therapeutic agents, particularly those targeting metabolic disorders. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in advanced synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of thiazolidinedione-based drug candidates for diabetes research.
• Biochemical Research: Used as a reference standard or ligand in studies investigating peroxisome proliferator-activated receptor (PPAR) activity.
• Process Chemistry: Employed in route scouting and scale-up development for active pharmaceutical ingredient (API) manufacturing.
• Academic Research: Serves as a specialized reagent in university and institutional labs for medicinal chemistry programs.
• Custom Synthesis: A starting material for the preparation of structurally related analogs for biological screening.

Basic Information

Product Name	5-[[4-[2-(5-Acetyl-2-Pyridinyl)Ethoxy]Phenyl]Methyl]-2,4Thiazolidinedione
CAS No.	146062-45-5
Molecular Formula	C20H18N2O4S
Molecular Weight	382.44 g/mol
Synonyms	5-[[4-[2-(5-Acetylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione; 5-[[4-[2-(5-Acetyl-2-pyridyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione; (R)-5-[[4-[2-(5-Acetyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione (enantiomer); A thiazolidinedione derivative; PPAR-gamma ligand intermediate; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of 5-[[4-[2-(5-Acetyl-2-Pyridinyl)Ethoxy]Phenyl]Methyl]-2,4Thiazolidinedione adheres to stringent quality management protocols. Each batch is characterized and tested to ensure identity, purity, and consistency suitable for research and development applications. A comprehensive Certificate of Analysis (COA) detailing results for assay, chiral purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.