Description

3-Fluorobicyclo[1.1.1]pentan-1-amine is a structurally unique, strained bicyclic amine derivative featuring a fluorine substituent. This compound matters as a valuable and versatile building block in modern synthetic chemistry, particularly for the development of novel pharmaceuticals and agrochemicals. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating new molecular entities with enhanced properties.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of active pharmaceutical ingredients (APIs), especially for incorporating the bioisosteric bicyclo[1.1.1]pentane (BCP) motif to improve metabolic stability and permeability.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides, where the fluorine atom and rigid BCP core can influence biological activity and environmental fate.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Employed as a linker or component in bifunctional molecules for targeted protein degradation, leveraging its three-dimensional structure and amine functionality.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the synthesis of specialty polymers and advanced materials with unique thermal or mechanical properties.
• Medicinal Chemistry Scaffold: Provides a saturated, three-dimensional core for fragment-based drug discovery and library synthesis to explore novel chemical space.
• Fluorine Chemistry Studies: Utilized in academic and industrial research to study the effects of fluorine substitution on the reactivity and physical properties of strained cage compounds.

Basic Information

Product Name	3-Fluorobicyclo[1.1.1]pentan-1-amine
CAS No.	146038-60-0
Molecular Formula	C5H8FN
Molecular Weight	101.12 g/mol
Synonyms	1-Amino-3-fluorobicyclo[1.1.1]pentane; 3-Fluoro-1-aminobicyclo[1.1.1]pentane; 3-Fluoro-BCP-amine; 3-Fluorobicyclo[1.1.1]pentan-1-ylamine; 3-Fluoro-1-bicyclo[1.1.1]pentylamine; 1-Bicyclo[1.1.1]pentanamine, 3-fluoro-; (3-Fluorobicyclo[1.1.1]pentan-1-yl)amine
EINECS	Contact for details

Quality Control

Our 3-Fluorobicyclo[1.1.1]pentan-1-amine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.