Description

2-(4-Carboxyphenyl)-4,4,5,5-Tetramethylimidazoline-1-Oxyl-3-Oxide CAS NO 145757-47-7 is a stable nitroxide radical compound, specifically a carboxylic acid-functionalized imidazoline nitroxide. This product is a critical spin label and spin trap in advanced research, enabling the study of molecular dynamics, structure, and free radical processes. It is essential for scientists and engineers in the fields of polymer chemistry, biophysics, and materials science who require precise tools for Electron Paramagnetic Resonance (EPR) spectroscopy and controlled radical polymerization.

Application

• Spin Labeling in Biophysics: Used to tag biomolecules (proteins, nucleic acids) for studying structure, dynamics, and conformational changes via EPR spectroscopy.
• Polymer Science & Controlled Radical Polymerization: Acts as a mediator or control agent in Nitroxide-Mediated Polymerization (NMP) for synthesizing polymers with well-defined architectures.
• Materials Research: Incorporated into polymers, liquid crystals, and other materials to probe local microenvironments, mobility, and phase transitions.
• Free Radical Detection (Spin Trapping): Employed to detect, identify, and quantify short-lived free radicals in chemical and biological systems.
• Antioxidant Activity Studies: Serves as a stable radical standard in assays evaluating the radical-scavenging capacity of novel compounds.
• Surface Functionalization: The carboxylic acid group allows for covalent attachment to surfaces, nanoparticles, or other matrices for creating functionalized interfaces.

Basic Information

Product Name	2-(4-Carboxyphenyl)-4,4,5,5-Tetramethylimidazoline-1-Oxyl-3-Oxide
CAS No.	145757-47-7
Molecular Formula	C14H17N2O4
Molecular Weight	277.30 g/mol
Synonyms	4-Carboxy-PTIO; 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide; 4-Carboxy-2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide; PTIO-4-COOH; Carboxy-PTIO; 4-Carboxyphenyl-PTIO; 1-Oxyl-2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazolidin-3-one-3-oxide; 4-Carboxy-PTIO free radical
EINECS	Contact for details

Quality Control

Our production of this high-purity spin label adheres to strict analytical standards to ensure batch-to-batch consistency and reliability for sensitive research applications. Quality is verified through techniques including HPLC, EPR spectroscopy, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and radical content is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. Keep the container in a dry, cool, and well-ventilated area. For long-term stability, desiccate if necessary.

Specification

Item	Specification
Appearance	Orange to red powder or crystals
Identification (IR)	Conforms to structure
Identification (EPR)	Characteristic triplet signal
Purity (HPLC)	≥ 98.0%
Radical Content (EPR)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.