Description

Sphingofungin F CAS NO 145401-48-5 is a potent and specific inhibitor of serine palmitoyltransferase (SPT), a key enzyme in the *de novo* biosynthesis of sphingolipids. This targeted mode of action makes it a critical research tool for studying sphingolipid metabolism and its role in cellular processes such as apoptosis, signal transduction, and membrane biology. It is primarily utilized by researchers in pharmaceutical R&D, biotechnology, and academic institutions for biochemical and pharmacological studies.

Application

• Biochemical Research: Used as a specific inhibitor to study the sphingolipid biosynthetic pathway and its regulation.
• Cell Biology Studies: Employed to investigate the role of sphingolipids in cell growth, differentiation, and programmed cell death (apoptosis).
• Pharmacology & Drug Discovery: Serves as a reference compound and lead structure for developing novel therapeutics targeting sphingolipid-related diseases.
• Enzyme Inhibition Assays: Acts as a standard inhibitor in *in vitro* assays to characterize serine palmitoyltransferase (SPT) activity.
• Academic Research: A valuable tool for universities and research institutes exploring lipid metabolism and membrane biology.

Basic Information

Product Name	Sphingofungin F
CAS No.	145401-48-5
Molecular Formula	C21H39NO5
Molecular Weight	385.54 g/mol
Synonyms	Sphingofungin F; Antibiotic 1799; (2S,3S,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-methyl-6-eicosenoic acid; Sphingofungin; L-1799; Serine palmitoyltransferase inhibitor; SPT inhibitor
EINECS	Contact for details

Quality Control

Our Sphingofungin F is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee product integrity and support your research documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a desiccator to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.