Description

1-(2-Chloro-Acetyl)-Piperazine Hcl is a versatile and high-purity pharmaceutical intermediate, essential for the synthesis of complex active pharmaceutical ingredients (APIs). Its core value lies in providing a reactive chloroacetyl group attached to a piperazine scaffold, enabling critical amide bond formation and structural diversification in drug discovery. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing new therapeutic and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of various drug candidates, particularly those targeting the central nervous system and infectious diseases.
• API Synthesis: Used in the production of Active Pharmaceutical Ingredients (APIs) that require a piperazine moiety with a reactive handle for further functionalization.
• Agrochemical Research: Serves as a precursor in the development of novel herbicides, fungicides, and insecticides.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new chemical entities and reaction pathways.
• Custom Synthesis: A critical starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	1-(2-Chloro-Acetyl)-Piperazine Hcl
CAS No.	145222-00-0
Molecular Formula	C6H12ClN2O • HCl
Molecular Weight	209.09 g/mol
Synonyms	1-(2-Chloroacetyl)piperazine hydrochloride; 2-Chloro-1-(piperazin-1-yl)ethanone hydrochloride; N-(2-Chloroacetyl)piperazine hydrochloride; 2-Chloro-1-piperazin-1-ylethanone hydrochloride; Chloroacetylpiperazine HCl; Piperazine, 1-(chloroacetyl)-, hydrochloride; 145222-00-0; N-Chloroacetylpiperazine hydrochloride
EINECS	Contact for details

Quality Control

Our 1-(2-Chloro-Acetyl)-Piperazine Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive quality assurance, with products typically meeting specifications suitable for pharmaceutical research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.