Description

Methyl 4-Hydroxypiperidine-2-Carboxylate is a versatile chiral piperidine derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its bifunctional nature, featuring both a hydroxyl group and an ester moiety on a saturated nitrogen heterocycle, enabling its use in constructing complex molecular architectures. It is primarily sought after by pharmaceutical R&D and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of various drug candidates, particularly those targeting the central nervous system (CNS) and as a precursor for protease inhibitors.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the piperidine scaffold contributes to biological activity.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands for asymmetric catalysis, enhancing the efficiency of stereoselective reactions.
• Fine Chemical Building Block: Integral for constructing complex natural product analogs and other high-value specialty chemicals in research and pilot-scale production.
• Academic and Industrial Research: Serves as a standard reagent in medicinal chemistry and process development laboratories for method exploration and scale-up studies.

Basic Information

Product Name	Methyl 4-Hydroxypiperidine-2-Carboxylate
CAS No.	144913-66-6
Molecular Formula	C7H13NO3
Molecular Weight	159.18 g/mol
Synonyms	Methyl 4-hydroxypiperidine-2-carboxylate; 4-Hydroxy-2-piperidinecarboxylic acid methyl ester; Methyl 4-hydroxypiperidine-2-carboxylate; Methyl 4-hydroxy-2-piperidinecarboxylate; 2-Piperidinecarboxylic acid, 4-hydroxy-, methyl ester; Methyl 4-hydroxypiperidine-2-carboxylate (enantiomer); 4-Hydroxy-piperidine-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Every batch of Methyl 4-Hydroxypiperidine-2-Carboxylate is manufactured under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent chiral integrity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.