Description

Acetic Acid, [4-[3-[(6-Amino-1,2,3,4-Tetrahydro-2,4-Dioxo-1,3-Dipropyl-5-Pyrimidinyl)Amino]-2-Methyl-3-Oxopropyl]Phenoxy]-, 1,1-Dimethylethyl Ester, (-)- is a high-purity, chiral pharmaceutical intermediate of significant commercial and research interest. This compound is a key synthetic precursor in the development of advanced therapeutic agents, particularly in the fields of cardiology and metabolic disease. It is essential for pharmaceutical manufacturers and R&D laboratories engaged in the synthesis of complex, biologically active molecules requiring stringent quality control.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel adenosine receptor antagonists and related active pharmaceutical ingredients (APIs).
• Cardiovascular Drug Research: Used in the development of targeted therapies for conditions such as heart failure and arrhythmias.
• Metabolic Disorder Therapeutics: Serves as a precursor in the manufacture of drugs targeting metabolic pathways.
• Chiral Synthesis: Provides the (-)-enantiomer for stereoselective synthesis, crucial for producing drugs with specific biological activity.
• Process Chemistry & Scale-Up: Employed in process development and optimization for commercial-scale API manufacturing.
• Biochemical Research: Used as a tool compound in pharmacological studies to investigate receptor mechanisms and signal transduction.

Basic Information

Item	Details
Product Name	Acetic Acid, [4-[3-[(6-Amino-1,2,3,4-Tetrahydro-2,4-Dioxo-1,3-Dipropyl-5-Pyrimidinyl)Amino]-2-Methyl-3-Oxopropyl]Phenoxy]-, 1,1-Dimethylethyl Ester, (-)-
CAS No.	144872-07-1
Molecular Formula	C28H42N4O6
Molecular Weight	530.66 g/mol
Synonyms	(-)-MRS 1754; (R)-MRS 1754; MRS 1754 (-)-enantiomer; N-[4-[3-[(6-Amino-1,3-dipropyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)amino]-2-methyl-1-oxopropyl]phenoxy]acetic acid 1,1-dimethylethyl ester; tert-Butyl (R)-2-(4-((3-((6-amino-1,3-dipropyl-2,4-dioxo-1,2,3,4-tetrahydro-5H-pyrimidin-5-yl)amino)-2-methyl-1-oxopropan-2-yl)oxy)phenyl)acetate; A2B Adenosine Receptor Antagonist (MRS 1754); BVT.115959
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict cGMP guidelines to ensure batch-to-batch consistency and traceability. Quality is verified through a comprehensive analytical package including HPLC for chiral purity and assay, residual solvent analysis, and identity confirmation. A detailed Certificate of Analysis (COA) is provided with each batch, documenting compliance with client-specific or internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccated environment after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.