Description

1,25-Dihydroxy-19-Norprevitamin D3 is a high-purity, advanced synthetic intermediate and reference standard in the vitamin D analog family. This compound is critical for research and development in the pharmaceutical sector, particularly for studying novel therapeutic pathways related to calcium metabolism and cell differentiation. It is primarily utilized by R&D laboratories, academic institutions, and manufacturers developing next-generation treatments for osteoporosis, psoriasis, and secondary hyperparathyroidism.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of advanced, non-calcemic vitamin D receptor modulators and analogs for clinical research.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control of related pharmaceutical compounds.
• Biochemical Research: Essential for in-vitro and in-vivo studies investigating the mechanisms of vitamin D action, gene regulation, and hormone signaling pathways.
• Drug Discovery: Serves as a building block in medicinal chemistry programs aimed at creating new therapeutics for bone disorders, autoimmune diseases, and certain cancers.
• Metabolite Studies: Employed in metabolic pathway analysis to understand the biotransformation and activity of vitamin D-related compounds.

Basic Information

Product Name	1,25-Dihydroxy-19-Norprevitamin D3
CAS No.	144699-06-9
Molecular Formula	C26H42O3
Molecular Weight	402.61 g/mol
Synonyms	19-Nor-1,25-dihydroxyprevitamin D3; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol; 1α,25-Dihydroxy-19-norprevitamin D3; 19-Nor-1α,25-dihydroxyprevitamin D3; 19-Norprevitamin D3-1,25-diol
EINECS	Contact for details

Quality Control

Our 1,25-Dihydroxy-19-Norprevitamin D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., argon or nitrogen) at controlled room temperature (15-25°C) or as specified on the label or COA. This material is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.