Description

(2-Methoxy-3-Octadecyloxy)Propyl-1-Phosphocholine is a synthetic phospholipid derivative, specifically a phosphocholine analog with a long-chain alkyl ether linkage. This compound is valued for its role as a key intermediate in the synthesis of advanced lipid-based materials and biomimetic systems. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for developing novel drug delivery vehicles, liposomal formulations, and membrane model studies.

Application

• Lipid Nanoparticle (LNP) and Liposome Formulation: A critical building block for constructing stable, targeted drug delivery systems for mRNA, siRNA, and other therapeutic agents.
• Biomimetic Membrane Research: Used to create synthetic lipid bilayers and vesicles for studying membrane protein interactions, permeability, and cellular processes.
• Phospholipid Prodrug Synthesis: Serves as a versatile intermediate for the chemical conjugation of active pharmaceutical ingredients (APIs) to create phospholipid prodrugs with enhanced bioavailability.
• Surface Modification Agent: Imparts biocompatible and stealth properties to nanoparticles and medical device surfaces to reduce immune recognition.
• Reference Standard and Analytical Chemistry: Employed as a high-purity standard in quality control (QC) and research & development (R&D) laboratories for method development and validation.

Basic Information

Product Name	(2-Methoxy-3-Octadecyloxy)Propyl-1-Phosphocholine
CAS No.	144260-36-6
Molecular Formula	C₂₇H₅₈NO₆P
Molecular Weight	523.73 g/mol
Synonyms	1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphocholine; rac-1-O-Octadecyl-2-O-methylglycero-3-phosphocholine; 1-O-Octadecyl-2-O-methyl-sn-glycero-3-phosphocholine; O-Methyl-O'-octadecylphosphatidylcholine; Ether Lipid PC(18:0/0:0/2:0); Glycerophosphocholine derivative; Phosphocholine lipid intermediate
EINECS	Contact for details

Quality Control

Our (2-Methoxy-3-Octadecyloxy)Propyl-1-Phosphocholine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid/waxy solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.