Description

2-Piperazineaceticacid,3,6-Dioxo-,Methylester,(R)-(9Ci) is a high-purity chiral piperazine derivative, a critical building block in advanced organic synthesis. Its value lies in providing a stereochemically defined scaffold for constructing complex molecules with precise biological activity. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, including protease inhibitors and other small-molecule drugs.
• Peptidomimetic Chemistry: Serves as a constrained, non-natural amino acid analog for designing and synthesizing peptide mimics with enhanced metabolic stability and bioavailability.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or building block in stereoselective synthesis to introduce the (R)-configuration into target molecules.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical entities.
• Fine Chemical Production: Used in the custom synthesis of specialized, high-value compounds for agrochemical and material science applications.
• Bioconjugation: Potential use in linker chemistry for creating antibody-drug conjugates (ADCs) or other targeted delivery systems due to its functionalized piperazine core.

Basic Information

Product Name	2-Piperazineaceticacid,3,6-Dioxo-,Methylester,(R)-(9Ci)
CAS No.	144239-67-8
Molecular Formula	C7H10N2O4
Molecular Weight	186.17 g/mol
Synonyms	(R)-Methyl 3,6-dioxopiperazine-2-acetate; (R)-2-(3,6-Dioxopiperazin-2-yl)acetic acid methyl ester; Methyl (R)-2-(3,6-dioxopiperazin-2-yl)acetate; (R)-Piperazine-2-acetic acid, 3,6-dioxo-, methyl ester; (2R)-2-(3,6-Dioxopiperazin-2-yl)acetic acid methyl ester; (R)-3,6-Dioxopiperazine-2-acetic acid methyl ester; (R)-DKP-AA-OMe
EINECS	Contact for details

Quality Control

Our 2-Piperazineaceticacid,3,6-Dioxo-,Methylester,(R)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with high-purity research and pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.