Description

(R)-3-Isopropyl-2,5-Piperazinedione CAS NO 143673-66-9 is a high-purity chiral piperazinedione derivative, a crucial building block in advanced pharmaceutical synthesis. Its primary value lies in its role as a key intermediate for the development of novel active pharmaceutical ingredients (APIs), particularly in chiral drug discovery and asymmetric synthesis. This compound is essential for research and production teams in the pharmaceutical, biotechnology, and fine chemical industries seeking to develop new therapeutic agents with high stereochemical purity.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of complex drug molecules, including protease inhibitors and other biologically active compounds.
• Asymmetric Synthesis: Used as a starting material or auxiliary in catalytic asymmetric reactions to introduce stereogenic centers.
• Peptidomimetic Research: Serves as a constrained scaffold in the design and development of peptide mimics for drug discovery programs.
• API Development: Integral to the research and scale-up process for new Active Pharmaceutical Ingredients requiring high enantiomeric purity.
• Chemical Biology Probes: Utilized in the creation of specialized probes for studying enzyme mechanisms and protein interactions.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for high-value, specialty chemicals.

Basic Information

Product Name	(R)-3-Isopropyl-2,5-Piperazinedione
CAS No.	143673-66-9
Molecular Formula	C7H12N2O2
Molecular Weight	156.18 g/mol
Synonyms	(R)-3-Isopropylpiperazine-2,5-dione; (R)-3-(1-Methylethyl)-2,5-piperazinedione; (R)-3-Isopropyl-2,5-diketopiperazine; (R)-3-Isopropyl-DKP; (R)-3-Isopropyl-2,5-dioxopiperazine; (R)-3-(Propan-2-yl)piperazine-2,5-dione; (3R)-3-Isopropylpiperazine-2,5-dione
EINECS	Contact for details

Quality Control

Our (R)-3-Isopropyl-2,5-Piperazinedione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, to ensure it meets the high-purity standards required for pharmaceutical R&D and cGMP applications. Certificates of Analysis (COA) detailing purity, identity, and chiral purity are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep the container tightly sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.