Description

C2 L-Threo Ceramide (D18:1/2:0) CAS NO 143615-69-4 is a high-purity, synthetic sphingolipid characterized by its specific L-threo stereochemistry and defined acyl chain lengths. This compound is critical for advanced research and development in lipid biology and skin barrier function studies. It is primarily utilized by scientists and formulators in the cosmetic, pharmaceutical, and life science research industries for its role as a key structural and signaling molecule.

Application

• Biomedical Research: As a standard or reagent for studying sphingolipid metabolism, cell signaling pathways, apoptosis, and membrane biophysics.
• Cosmetic Science & Dermocosmetics: A key active ingredient in premium skincare formulations aimed at restoring and enhancing the skin's natural lipid barrier, improving hydration, and reducing transepidermal water loss (TEWL).
• Pharmaceutical Development: Investigated for use in topical drug delivery systems and as a potential therapeutic agent for dermatological conditions related to barrier dysfunction.
• Analytical Standard: Used as a reference standard in HPLC, LC-MS, and other analytical methods for the quantification and qualification of ceramides in complex biological or cosmetic matrices.
• Lipidomics: An essential component in lipidomic studies to understand lipid profiles and their implications in health and disease states.
• Model Membrane Systems: Incorporated into liposomes and other artificial membrane models to study bilayer properties and lipid-protein interactions.

Basic Information

Product Name	C2 L-Threo Ceramide (D18:1/2:0)
CAS No.	143615-69-4
Molecular Formula	C₂₀H₃₉NO₃
Molecular Weight	341.53 g/mol
Synonyms	N-Acetylsphingosine; N-Acetyl-D-erythro-sphingosine (L-Threo isomer); Ceramide (d18:1/2:0); (2S,3R,4E)-2-Acetamido-4-octadecene-1,3-diol; L-threo-C2-Ceramide; N-Acetyl-D-erythro-sphingosine; N-Acetylceramide; Synthetic Ceramide II
EINECS	Contact for details

Quality Control

Our C2 L-Threo Ceramide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and formulation. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. For long-term storage, desiccate at -20°C. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.