Description

2-(Hydroxymethyl)-1,4-Piperazinedicarboxylic Acid 1,4-Bis(tert-Butyl) Ester is a high-purity, protected piperazine derivative that serves as a critical building block in advanced organic synthesis. Its value lies in providing a versatile, reactive scaffold with orthogonal protecting groups, enabling the controlled construction of complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel bioactive compounds. CAS number is provided in the table below.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex drug molecules, particularly those containing piperazine or morpholine cores.
• Peptidomimetic Research: Used in the design and synthesis of peptide analogs and protease inhibitors due to its hydroxymethyl functionality.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts in asymmetric synthesis.
• Agrochemical Synthesis: Intermediate in the production of advanced crop protection agents and herbicides.
• Polymer Chemistry: Can be utilized as a monomer or cross-linking agent for specialty polymers and dendrimers.
• Chemical Biology Probes: Foundation for creating molecular probes and tools for studying biological pathways.

Basic Information

Product Name	2-(Hydroxymethyl)-1,4-Piperazinedicarboxylic Acid 1,4-Bis(tert-Butyl) Ester
CAS No.	143540-05-0
Molecular Formula	C15H28N2O5
Molecular Weight	316.40 g/mol
Synonyms	1,4-Bis(tert-butoxycarbonyl)-2-(hydroxymethyl)piperazine; 2-(Hydroxymethyl)piperazine-1,4-dicarboxylic acid di-tert-butyl ester; N,N'-Di-Boc-2-(hydroxymethyl)piperazine; 1-Boc-4-Boc-2-(hydroxymethyl)piperazine; tert-Butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate; 2-Piperazinemethanol, 1,4-bis(1,1-dimethylethyl) ester; (2-Hydroxymethyl)piperazine-1,4-dicarboxylic Acid Di-tert-butyl Ester
EINECS	Contact for details

Quality Control

Our 2-(Hydroxymethyl)-1,4-Piperazinedicarboxylic Acid 1,4-Bis(tert-Butyl) Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profile, and physical characteristics are provided with every shipment to support your R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.