Description

1-Piperidinecarboxylic Acid, 4-Hydroxy-3,3-Dimethyl-, 1,1-Dimethylethyl Ester is a high-purity, protected amino acid derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in providing a sterically hindered, optically active piperidine scaffold, which is essential for constructing complex molecules with precise stereochemistry. This compound is primarily needed by pharmaceutical R&D and fine chemical manufacturers for developing active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, especially those targeting the central nervous system (CNS) and anti-infective therapies.
• Agrochemical Research: Used in the development of novel, high-efficacy pesticides and herbicides that require specific stereoisomers for optimal activity.
• Asymmetric Catalysis: Employed as a precursor for chiral ligands or catalysts used in enantioselective synthesis.
• Peptidomimetics: Integral for constructing non-natural amino acid residues in peptide-based drug discovery programs.
• Academic & Contract Research: Serves as a valuable reagent for methodological development and the synthesis of novel chemical entities in research laboratories.
• Custom Synthesis: A starting material for contract manufacturing organizations (CMOs) producing bespoke fine chemicals for client projects.

Basic Information

Product Name	1-Piperidinecarboxylic Acid, 4-Hydroxy-3,3-Dimethyl-, 1,1-Dimethylethyl Ester
CAS No.	143306-65-4
Molecular Formula	C12H23NO3
Molecular Weight	229.32 g/mol
Synonyms	tert-Butyl 4-hydroxy-3,3-dimethylpiperidine-1-carboxylate; 4-Hydroxy-3,3-dimethylpiperidine-1-carboxylic acid tert-butyl ester; Boc-4-Hydroxy-3,3-dimethylpiperidine; 1-Boc-4-hydroxy-3,3-dimethylpiperidine; 3,3-Dimethyl-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester; N-Boc-4-hydroxy-3,3-dimethylpiperidine; 1-(tert-Butoxycarbonyl)-4-hydroxy-3,3-dimethylpiperidine
EINECS	Contact for details

Quality Control

Our 1-Piperidinecarboxylic Acid, 4-Hydroxy-3,3-Dimethyl-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.