Description

Sodium (R)-1-[(1-{3-[2-(7-Chloro-2-Quinolyl)Vinyl]Phenyl}-3-[2-(1-Hydroxy-1- is a high-purity, non-racemic chiral intermediate of significant importance in advanced pharmaceutical synthesis. This compound is specifically valued for its role in constructing complex molecular architectures, particularly in the development of targeted therapeutics. It is a critical building block for research chemists and process development scientists in the pharmaceutical and biotechnology industries, enabling the production of enantiomerically pure active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, particularly in oncology and anti-inflammatory research.
• Asymmetric Synthesis: Used in catalytic and stoichiometric reactions to introduce stereochemical complexity into target molecules.
• API Development: Serves as a critical precursor in the research, development, and scale-up of enantiomerically pure active pharmaceutical ingredients.
• Process Chemistry: Employed in route scouting and optimization for more efficient and cost-effective manufacturing processes.
• Bioconjugation Research: Potential use in creating labeled compounds or antibody-drug conjugates (ADCs) for diagnostic or therapeutic purposes.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) exploring new synthetic methodologies and biological targets.

Basic Information

Product Name	Sodium (R)-1-[(1-{3-[2-(7-Chloro-2-Quinolyl)Vinyl]Phenyl}-3-[2-(1-Hydroxy-1-
CAS No.	142522-81-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(R)-Montelukast Sodium; Sodium (R)-Montelukast; (R)-MK-0476; (R)-1-(((1-(R)-(3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid sodium salt; (R)-Singulair; (R)-Montelukast; (R)-Leukotriene D4 receptor antagonist
EINECS	Contact for details

Quality Control

Our Sodium (R)-1-[(1-{3-[2-(7-Chloro-2-Quinolyl)Vinyl]Phenyl}-3-[2-(1-Hydroxy-1- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting standards for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.