Description

1-Hydroxymethyl-3-Norhydroxy-3,25-Dihydroxyvitamin D3 is a high-purity, synthetic vitamin D3 analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate and reference standard for the synthesis of novel therapeutic agents targeting vitamin D receptor pathways. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on developing treatments for conditions related to calcium metabolism, cell differentiation, and immune modulation. The precise molecular structure of this analog allows for targeted studies into receptor binding affinity and metabolic activity.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel vitamin D analogs and prodrugs for clinical development.
• Reference Standard: Used as a high-purity analytical standard in HPLC, LC-MS, and NMR for quality control and method validation in API manufacturing.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate the structure-activity relationships (SAR) of vitamin D receptor (VDR) ligands.
• Metabolic Pathway Studies: Facilitates research into the hydroxylation pathways and metabolic fate of vitamin D3 analogs.
• Drug Discovery: A valuable tool for screening and developing new therapeutic candidates for osteoporosis, psoriasis, and certain cancers.

Basic Information

Product Name	1-Hydroxymethyl-3-Norhydroxy-3,25-Dihydroxyvitamin D3
CAS No.	142508-68-7
Molecular Formula	C₂₈H₄₄O₄
Molecular Weight	444.65 g/mol
Synonyms	1α-Hydroxymethyl-3-deoxy-1α,25-dihydroxyvitamin D3; 1α-(Hydroxymethyl)-3-deoxy-1α,25-dihydroxycholecalciferol; 3-Deoxy-1α-(hydroxymethyl)-1α,25-dihydroxyvitamin D3; 1-Hydroxymethyl-3-nor-1,25-dihydroxyvitamin D3; Vitamin D3 analog 142508-68-7; 1α-HMD 1,25-(OH)2D3; (1R,3aR,7aS)-1-[(2R)-6-[(E,2R,5S)-5-[(2R)-3,3-Dimethyloxiran-2-yl]-3-methylpent-2-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-yl]-2-methylpropane-1,2-diol
EINECS	Contact for details

Quality Control

Our 1-Hydroxymethyl-3-Norhydroxy-3,25-Dihydroxyvitamin D3 is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for research and development purposes. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While produced to meet exacting internal standards, this product is offered for R&D use and is not intended for human or veterinary drug application without further processing and regulatory approval.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) or as specified on the label or COA. Due to its sensitivity to light and oxidation, prolonged exposure to air or light should be avoided. Keep the container tightly sealed in a dry, cool, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.