Description

2-Pyrrolidinemethanamine, 1-(3-Propylphenyl)-, (-)-, (E)-2-Butenedioat E (1:1) is a high-purity chiral amine salt, specifically the fumarate salt of a substituted pyrrolidine derivative, which serves as a critical building block in advanced organic synthesis. Its defined stereochemistry and salt form provide enhanced stability and handling properties for precise pharmaceutical and agrochemical research. This compound is essential for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), agrochemicals, and other fine chemical intermediates requiring a specific enantiomeric scaffold.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and cardiovascular drug candidates.
• Agrochemical Synthesis: Used as a precursor in the manufacture of advanced, enantiomerically pure pesticides and herbicides.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing specialized ligands used in chiral catalysis.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals and flavors & fragrances.
• Academic & Institutional Research: A valuable reagent for methodological studies in organic chemistry and pharmacology within R&D laboratories.
• Process Chemistry & Scale-Up: Supports route scouting and optimization for the commercial-scale production of chiral molecules.

Basic Information

Product Name	2-Pyrrolidinemethanamine, 1-(3-Propylphenyl)-, (-)-, (E)-2-Butenedioat E (1:1)
CAS No.	142469-99-6
Molecular Formula	C18H26N2O4
Molecular Weight	334.41 g/mol
Synonyms	(-)-1-(3-Propylphenyl)-2-pyrrolidinemethanamine (E)-2-butenedioate (1:1); (R)-1-(3-Propylphenyl)-2-(aminomethyl)pyrrolidine fumarate; Fumaric acid, compd. with (2R)-1-(3-propylphenyl)-2-pyrrolidinemethanamine (1:1); (2R)-1-(3-Propylphenyl)-2-pyrrolidinemethanamine fumarate; (R)-1-(3-Propylbenzyl)-2-aminomethylpyrrolidine fumarate salt; (R)-1-(3-n-Propylphenyl)-2-(aminomethyl)pyrrolidine fumarate; Chiral pyrrolidine amine fumarate salt; CAS 142469-99-6
EINECS	Contact for details

Quality Control

Our production of 2-Pyrrolidinemethanamine, 1-(3-Propylphenyl)-, (-)-, (E)-2-Butenedioat E (1:1) adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. We operate under a cGMP-compliant quality management system, and our analytical methods, including chiral HPLC, are fully validated to meet the exacting standards of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for prolonged operations to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.