Description

Bis(3,5-Di(trifluoromethyl)phenyl)chlorophosphine is a highly specialized organophosphorus reagent featuring electron-deficient aryl groups. This compound is a critical building block in advanced chemical synthesis, valued for its role in constructing complex ligand frameworks and facilitating challenging coupling reactions. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and materials science sectors for the development of novel catalysts and functional molecules.

Application

• Pharmaceutical Intermediate Synthesis: A key precursor for the preparation of sophisticated phosphine ligands used in asymmetric catalysis and cross-coupling reactions (e.g., Buchwald-Hartwig amination).
• Agrochemical Research: Employed in the development of new active ingredients and plant protection agents that require fluorinated phosphine components.
• Catalyst Development: Serves as a foundational unit for constructing bulky, electron-poor phosphine ligands essential for catalyzing reactions with sensitive or sterically hindered substrates.
• Materials Science: Used in the synthesis of novel organometallic complexes and polymers where the introduction of fluorinated arylphosphine groups can modify electronic properties and stability.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic and organometallic chemistry, particularly in exploring new reaction pathways.

Basic Information

Product Name	Bis(3,5-Di(trifluoromethyl)phenyl)chlorophosphine
CAS No.	142421-57-6
Molecular Formula	C16H6ClF12P
Molecular Weight	516.62 g/mol
Synonyms	Chlorobis[3,5-bis(trifluoromethyl)phenyl]phosphine; Bis[3,5-bis(trifluoromethyl)phenyl]chlorophosphine; Bis(3,5-bis(trifluoromethyl)phenyl)phosphinous chloride; (3,5-Bis(trifluoromethyl)phenyl)chlorophosphine dimer; Chloro-bis(3,5-di(trifluoromethyl)phenyl)phosphine
EINECS	Contact for details

Quality Control

Our Bis(3,5-Di(trifluoromethyl)phenyl)chlorophosphine is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. Products undergo rigorous analytical testing, including NMR and HPLC, to verify identity and assay. A comprehensive Certificate of Analysis (COA) detailing purity and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (argon or nitrogen) when not in use. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
31P NMR	Conforms
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.