Description

Pyruvic-13C3 Acid Sodium Salt is a stable, isotopically labeled sodium salt of pyruvic acid, where all three carbon atoms are the 13C isotope. This high-purity compound is essential for metabolic pathway research, providing a critical tracer for accurate quantification and mechanistic studies using techniques like NMR and mass spectrometry. It is primarily utilized by researchers and manufacturers in pharmaceutical development, clinical diagnostics, and advanced biochemical research requiring precise isotopic enrichment.

Application

• Metabolic Flux Analysis (MFA): As a key 13C-labeled precursor for tracing carbon flow in central metabolic pathways such as glycolysis, gluconeogenesis, and the TCA cycle in cell cultures and in vivo studies.
• Pharmaceutical Research & Drug Development: Used in the synthesis of isotopically labeled drug candidates and metabolites for pharmacokinetic (PK) and absorption, distribution, metabolism, and excretion (ADME) studies.
• Clinical Diagnostics & Biomarker Discovery: Serves as an internal standard in quantitative LC-MS/MS and GC-MS assays for accurate measurement of pyruvate and related metabolites in biological fluids.
• Nutritional and Sports Science Research: Employed in studies investigating energy metabolism, mitochondrial function, and the biochemical effects of supplements.
• Stable Isotope Labeling in Cell Culture (SILAC) and Proteomics: Facilitates the study of protein turnover and synthesis rates when incorporated into culture media.
• Enzymology Studies: Acts as a substrate for enzymes like lactate dehydrogenase (LDH) and alanine aminotransferase (ALT) in mechanistic and inhibition studies.

Basic Information

Product Name	Pyruvic-13C3 Acid Sodium Salt
CAS No.	142014-11-7
Molecular Formula	13C3H3NaO3
Molecular Weight	113.03 g/mol (for 13C3 labeled form)
Synonyms	Sodium Pyruvate-13C3; 2-Oxopropanoic-13C3 Acid Sodium Salt; Pyruvic Acid-13C3 Sodium Salt; Sodium 2-Oxopropanoate-13C3; (13C3)Pyruvic Acid Sodium Salt; 13C3-Labeled Sodium Pyruvate; 2-Oxopropionic-13C3 Acid Sodium Salt; [13C3]-Sodium Pyruvate
EINECS	Contact for details

Quality Control

Our Pyruvic-13C3 Acid Sodium Salt is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity, critical for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically >99 atom % 13C), chemical purity (by HPLC/NMR), and other critical parameters. We adhere to relevant industry standards for research chemicals, and custom purity grades or specific analytical data packages are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥99 atom % 13C
Isotopic Purity (by MS)	≥99% 13C3
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.1%
pH (5% solution)	6.0 - 8.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.