Description

(2S)-2-[4-(2-Methylpropyl)Phenyl]Propanoic Acid CAS NO 141505-32-0 is a high-purity, single-enantiomer chiral compound belonging to the arylpropionic acid class. This specific stereoisomer is of significant commercial interest for its role as a key chiral intermediate in the synthesis of advanced active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical R&D and manufacturing sectors for the development of non-steroidal anti-inflammatory drugs (NSAIDs) and other therapeutic agents where stereochemical purity is critical for efficacy and safety.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of enantiomerically pure NSAIDs and other proprietary drug molecules.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for new chemical entities targeting inflammation and pain.
• Asymmetric Synthesis: Serves as a valuable starting material or resolving agent in chiral synthesis and catalysis studies.
• Reference Standard: Employed as a high-purity analytical standard for method development and quality control in pharmaceutical laboratories.
• Biochemical Research: Used in studies investigating enzyme-substrate interactions and metabolic pathways involving chiral carboxylic acids.
• Fine Chemical Synthesis: A versatile intermediate for creating more complex, value-added specialty chemicals with defined stereochemistry.

Basic Information

Product Name	(2S)-2-[4-(2-Methylpropyl)Phenyl]Propanoic Acid
CAS No.	141505-32-0
Molecular Formula	C13H18O2
Molecular Weight	206.28 g/mol
Synonyms	(S)-2-(4-Isobutylphenyl)propanoic acid; (S)-Ibuprofen; Dexibuprofen (Free Acid); (S)-(+)-Ibuprofen; (2S)-2-(4-Isobutylphenyl)propionic Acid; (S)-α-Methyl-4-(2-methylpropyl)benzeneacetic Acid; (S)-p-Isobutylhydratropic Acid; Dexibuprofen Impurity
EINECS	Contact for details

Quality Control

Our (2S)-2-[4-(2-Methylpropyl)Phenyl]Propanoic Acid is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral purity analysis, to ensure it meets the exacting standards required for pharmaceutical applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as enantiomeric excess (ee), chemical purity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.