Description

H2N-PEG5-CH2COOH is a heterobifunctional polyethylene glycol (PEG) derivative featuring a primary amine and a carboxylic acid group, separated by a flexible pentameric ethylene glycol spacer. This bifunctionality is critical for creating stable, hydrophilic linkers in bioconjugation and cross-linking applications, enabling the coupling of biomolecules with minimal steric hindrance. It is an essential reagent for researchers and manufacturers in pharmaceutical development, proteomics, and advanced material science, where precise and reliable molecular bridging is required.

Application

• Bioconjugation and Cross-linking: Used as a heterobifunctional linker to covalently attach peptides, proteins, or antibodies to surfaces, nanoparticles, or other molecules.
• PEGylation Reagent: Serves as a functionalized PEG spacer to modify therapeutic proteins or drug molecules, improving solubility, stability, and pharmacokinetics.
• Surface Functionalization: Employed to introduce amine or carboxyl groups onto materials (e.g., gold nanoparticles, quantum dots, polymers) for subsequent biomolecule immobilization.
• Hydrogel Synthesis: Acts as a building block in the creation of biocompatible and tunable hydrogels for drug delivery and tissue engineering scaffolds.
• Diagnostic Assay Development: Facilitates the preparation of labeled probes and capture molecules in immunoassays and biosensors.
• Solid-Phase Peptide Synthesis (SPPS): Can be used as a soluble or resin-bound handle for the synthesis of PEGylated peptides.

Basic Information

Product Name	H2N-PEG5-CH2COOH
CAS No.	141282-35-1
Molecular Formula	C15H31NO8
Molecular Weight	353.41 g/mol
Synonyms	5-Amino-3,6,9,12,15-pentaoxaheptadecan-17-oic acid; 17-Amino-4,7,10,13,16-pentaoxaheptadecanoic acid; Amino-PEG5-acetic acid; NH2-PEG5-COOH; α-Amino-ω-carboxy pentadeca(ethylene glycol); Amine-PEG5-acid; Heterobifunctional PEG, Amine and Acid; 8-Aza-4,7,10,13,16-pentaoxa-2-heptadecanoic acid
EINECS	Contact for details

Quality Control

Our H2N-PEG5-CH2COOH is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, consider sealing under argon or nitrogen. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.