Description

Decarestrictine A is a specialized, high-purity secondary metabolite originally isolated from *Penicillium* species, known for its potent biological activity. This compound is of significant interest for advanced research and development in life sciences due to its unique mechanism of action as a selective inhibitor of cholesterol biosynthesis. It serves as a critical reference standard and building block for pharmaceutical discovery, particularly for researchers and developers in the fields of oncology, metabolic disease, and enzymology.

Application

• Pharmaceutical R&D Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in drug discovery pipelines.
• Biochemical Research: Employed as a potent and selective tool compound to study the enzymatic activity and inhibition of squalene synthase and related pathways in cholesterol metabolism.
• Lead Compound Optimization: Serves as a sophisticated scaffold or intermediate for the semi-synthesis of novel analogs with potential therapeutic applications.
• Academic & Institutional Research: Utilized in university and government laboratories for fundamental studies in cell biology, pharmacology, and natural product chemistry.
• Bioactivity Screening: Incorporated into high-throughput screening (HTS) libraries to identify new biological targets or to validate assay systems.

Basic Information

Product Name	Decarestrictine A
CAS No.	140460-52-2
Molecular Formula	C22H34O5
Molecular Weight	378.51 g/mol
Synonyms	Decarestrictine A; (3R,4S,5S,7R,10S)-4,7,10-Trihydroxy-3,5,7,10-tetramethyl-1-oxaspiro[4.5]dec-2-one; L-731,033; Squalestatin S1; Zaragozic Acid A; ZA-A; Antibiotic L-731,033
EINECS	Contact for details

Quality Control

Every batch of Decarestrictine A is manufactured and analyzed under strict quality management systems. Our products undergo rigorous identity, purity, and potency testing using advanced analytical techniques including HPLC, NMR, and MS to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment to guarantee traceability and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. The product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.