Description

1,25-Dihydroxy-23-Oxavitamin D3 is a synthetic, biologically active vitamin D analog with a modified side chain, representing a key intermediate in the research and development of novel vitamin D receptor modulators. This compound is of significant interest for its potential to influence calcium metabolism and cellular differentiation pathways with a distinct pharmacological profile. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on endocrinology, oncology, and metabolic disease therapeutics.

Application

• Pharmaceutical Research & Development: A critical reference standard and synthetic intermediate for developing new vitamin D-based therapeutics targeting osteoporosis, psoriasis, and secondary hyperparathyroidism.
• Biochemical Research: Used as a high-purity ligand in studies investigating the structure-activity relationship (SAR) of the vitamin D receptor (VDR) and its signaling pathways.
• Metabolic Studies: Employed in preclinical research to explore the effects of modified vitamin D analogs on calcium and phosphate homeostasis.
• Fine Chemical Synthesis: Serves as a key building block for the custom synthesis of more complex vitamin D derivatives and prodrugs.
• Reference Material: Provides a certified standard for analytical method development, validation, and quality control in API manufacturing.

Basic Information

Product Name	1,25-Dihydroxy-23-Oxavitamin D3
CAS No.	140387-52-6
Molecular Formula	C₂₇H₄₂O₄
Molecular Weight	430.62 g/mol
Synonyms	23-Oxo-1,25-dihydroxyvitamin D3; 23-Oxocalcitriol; 1α,25-Dihydroxy-23-oxocholecalciferol; 1α,25-Dihydroxy-23-oxovitamin D3; 23-Keto-1,25-dihydroxyvitamin D3; (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4R)-4-hydroxy-1,5-dimethylhexa-2,5-dien-1-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
EINECS	Contact for details

Quality Control

Our 1,25-Dihydroxy-23-Oxavitamin D3 is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, purity, and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.