Description

Darbufelone Mesilate is a selective cyclooxygenase-2 (COX-2) inhibitor and 5-lipoxygenase (5-LOX) inhibitor, representing a dual-acting anti-inflammatory agent. This compound is of significant interest in pharmaceutical research and development for its potential to provide enhanced efficacy with a reduced side-effect profile compared to traditional NSAIDs. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of novel therapeutics for inflammatory and pain-related conditions.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for quality control and analytical method development in drug manufacturing.
• Biochemical Research: Used as a potent tool compound to study the mechanisms of COX-2 and 5-LOX inhibition and their roles in inflammation pathways.
• Preclinical Drug Development: Investigated in animal models for its pharmacokinetic, pharmacodynamic, and toxicological profile as a potential drug candidate.
• Active Pharmaceutical Ingredient (API) Intermediate: Employed in the synthesis and scale-up processes for developing final dosage forms.

Basic Information

Product Name	Darbufelone Mesilate
CAS No.	139340-56-0
Molecular Formula	C22H22N2O5S
Molecular Weight	426.49 g/mol
Synonyms	Darbufelone Mesylate; Darbufelone Methanesulfonate; CI-1004; PD-136095; 5-Methyl-2-(2,4-difluorophenyl)-4-[(4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone methanesulfonate; 5-Methyl-2-(2,4-difluorophenyl)-4-[4-(methylsulfonyl)phenyl]-2H-pyridazin-3-one methanesulfonate
EINECS	Contact for details

Quality Control

Our Darbufelone Mesilate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets high-purity standards suitable for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.