Description

Paricalcitol-5 is a synthetic analog of the active form of vitamin D, specifically designed for high-purity pharmaceutical applications. This compound is critical for the development of treatments targeting secondary hyperparathyroidism associated with chronic kidney disease. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in the formulation of injectable and oral medications, as well as in advanced biochemical research.

Application

• Active Pharmaceutical Ingredient (API) for the manufacture of injectable formulations used in hemodialysis patients.
• Key Intermediate in the synthesis of advanced vitamin D receptor activators for renal therapy.
• Reference Standard for quality control and analytical method development in pharmaceutical laboratories.
• Biochemical Research for studying calcium and phosphate metabolism, and vitamin D receptor signaling pathways.
• Formulation Development for oral solid dosage forms in clinical trial materials.

Basic Information

Product Name	Paricalcitol-5
CAS No.	139238-89-4
Molecular Formula	C₂₇H₄₄O₃
Molecular Weight	416.64 g/mol
Synonyms	19-Nor-1,25-dihydroxyvitamin D2; 19-Nor-1α,25-Dihydroxyvitamin D₂; Zemplar (Brand Name); Paricalcitol Impurity 5; (1R,3S)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4R)-4-hydroxy-1-methyl-2-hexen-1-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
EINECS	Contact for details

Quality Control

Our Paricalcitol-5 is manufactured under strict quality systems suitable for pharmaceutical ingredient supply. Each batch is tested to meet rigorous internal specifications for identity, purity, and potency, aligning with ICH guidelines. A comprehensive Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccated environment after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.