Description

Darbufelone is a selective cyclooxygenase-2 (COX-2) inhibitor and 5-lipoxygenase (5-LOX) inhibitor, representing a dual-acting anti-inflammatory agent. This mechanism is significant for its potential to provide effective inflammation and pain management with a reduced risk of gastrointestinal side effects compared to traditional NSAIDs. It is primarily utilized by pharmaceutical R&D organizations and manufacturers engaged in the development of novel therapeutic compounds for conditions such as arthritis and other inflammatory diseases. Darbufelone CAS NO 139226-30-5 is a key intermediate for researchers focusing on next-generation anti-inflammatory drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced anti-inflammatory drug candidates.
• Biomedical Research: Used as a reference standard or active compound in pharmacological studies targeting COX-2 and 5-LOX pathways.
• Drug Discovery Programs: Employed in high-throughput screening and lead optimization for developing new analgesic and anti-arthritic agents.
• Academic Research: Utilized in university and institutional labs for investigating the mechanisms of inflammation and evaluating new therapeutic strategies.

Basic Information

Product Name	Darbufelone
CAS No.	139226-30-5
Molecular Formula	C19H16N2O3S
Molecular Weight	352.41 g/mol
Synonyms	CI-1004; PD-136095; 5-Methoxy-3-(4-methanesulfonylphenyl)-2-phenyl-2,3-dihydro-1,3-thiazolo[3,2-a]pyrimidin-7-one; 2,3-Dihydro-5-methoxy-3-[(4-(methylsulfonyl)phenyl]-2-phenylthiazolo[3,2-a]pyrimidin-7-one; Thiazolopyrimidine derivative CI-1004
EINECS	Contact for details

Quality Control

Our Darbufelone is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assessment by HPLC, and control of specified impurities. Certificates of Analysis (COA) detailing all test results are provided to ensure traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.