Description

(R)-Piperazine-1,3-Dicarboxylic Acid 1-Benzyl Ester is a high-purity chiral building block of significant importance in modern pharmaceutical research and development. This compound serves as a key intermediate for the synthesis of complex molecules, particularly those targeting neurological and psychiatric disorders. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries to create novel active pharmaceutical ingredients (APIs) with high enantiomeric purity.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the development of central nervous system (CNS) active drugs, including potential treatments for depression, anxiety, and schizophrenia.
• Asymmetric Synthesis: Used in the construction of complex piperazine-based scaffolds where the (R)-configuration is essential for biological activity and receptor binding selectivity.
• Process Chemistry: Serves as a starting material or advanced intermediate in the scale-up and optimization of API manufacturing processes under Good Manufacturing Practice (GMP) guidelines.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization campaigns to improve drug candidate potency and metabolic stability.
• Reference Standard: Used as a high-purity analytical standard for method development and quality control in regulatory filings and batch release testing.

Basic Information

Product Name	(R)-Piperazine-1,3-Dicarboxylic Acid 1-Benzyl Ester
CAS No.	138812-69-8
Molecular Formula	C14H18N2O4
Molecular Weight	278.31 g/mol
Synonyms	(R)-1-Benzyl 3-Hydrogen Piperazine-1,3-dicarboxylate; (R)-1-Benzyloxycarbonyl-3-carboxypiperazine; (R)-1-CBZ-3-Carboxypiperazine; (R)-1-N-CBZ-3-Carboxypiperazine; (R)-3-Carboxy-1-(phenylmethoxy)carbonylpiperazine; (R)-Piperazine-1,3-dicarboxylic acid 1-benzyl ester; (R)-1-(Benzyloxycarbonyl)piperazine-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our (R)-Piperazine-1,3-Dicarboxylic Acid 1-Benzyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research and development work. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles. We adhere to relevant industry standards and can provide material suitable for use under cGMP guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Related Substances (HPLC)	Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.