Description

(R)-n-1-Boc-n-4-Cbz-2-Piperazine Carboxylic Acid CAS NO 138775-02-7 is a high-purity, chiral piperazine derivative serving as a critical building block in advanced organic synthesis. Its primary value lies in providing a protected, enantiomerically pure scaffold for constructing complex pharmaceutical intermediates, particularly for active pharmaceutical ingredients (APIs). This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-quality chiral synthons.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Peptidomimetic Research: Used in the design and construction of peptidomimetics and constrained peptides due to its rigid piperazine backbone and orthogonal protecting groups (Boc and Cbz).
• Asymmetric Synthesis: Employed in medicinal chemistry to introduce chiral centers and specific stereochemistry into target molecules during lead optimization.
• API Development: Integral in the research, development, and scale-up processes for new chemical entities (NCEs) and generic APIs.
• Chemical Biology Probes: Serves as a precursor for labeled compounds and molecular probes used in biochemical and pharmacological studies.
• Custom Synthesis & Contract Manufacturing: A requested substrate for custom synthesis projects requiring high stereochemical fidelity and reliable protection group chemistry.

Basic Information

Product Name	(R)-n-1-Boc-n-4-Cbz-2-Piperazine Carboxylic Acid
CAS No.	138775-02-7
Molecular Formula	C18H24N2O6
Molecular Weight	364.40 g/mol
Synonyms	(R)-1-Boc-4-Cbz-piperazine-2-carboxylic acid; (R)-1-(tert-Butoxycarbonyl)-4-(benzyloxycarbonyl)piperazine-2-carboxylic acid; (R)-N-Boc-N'-Cbz-piperazine-2-carboxylic acid; (2R)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-4-(phenylmethoxycarbonyl)piperazine-2-carboxylic acid; (R)-N1-Boc-N4-Cbz-2-piperazinecarboxylic acid; Boc-Cbz-(R)-piperazine-2-carboxylic acid; 138775-02-7; (R)-1,4-Bis-protected piperazine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our (R)-n-1-Boc-n-4-Cbz-2-Piperazine Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) are provided with each shipment, detailing specifications such as assay, enantiomeric excess, and impurity profiles. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.