Description

Hoe-140 CAS NO 138614-30-9 is a potent and selective bradykinin B2 receptor antagonist, widely recognized in pharmacological research. This compound is critical for investigating the role of the kallikrein-kinin system in various physiological and pathological processes. It is an essential research tool for scientists in the pharmaceutical, biotechnology, and academic sectors focused on cardiovascular research, inflammation, pain, and central nervous system studies.

Application

• Pharmacological Research: Primary tool for studying bradykinin B2 receptor-mediated pathways in vitro and in vivo.
• Cardiovascular Studies: Investigation of blood pressure regulation, vascular permeability, and heart failure models.
• Inflammation & Pain Research: Used to elucidate mechanisms in inflammatory diseases, neurogenic inflammation, and nociception.
• Central Nervous System (CNS) Research: Exploration of bradykinin's role in cerebral ischemia, blood-brain barrier function, and neurodegenerative conditions.
• Drug Discovery & Development: Serves as a reference standard and lead compound for developing novel therapeutic agents targeting the kinin system.
• Biomarker & Diagnostic Assay Development: Utilized in the development of assays to measure kinin system activity.

Basic Information

Product Name	Hoe-140
CAS No.	138614-30-9
Molecular Formula	C₆₀H₈₆N₁₈O₁₄S₂
Molecular Weight	1307.6 g/mol
Synonyms	Icatibant; D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg; HOE-140; JE 049; JE049; Bradykinin B2 Receptor Antagonist; B-9430; (R)-1-[[2,3-Dihydro-1-(2-methylphenacyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]carbonyl]-L-proline
EINECS	Contact for details

Quality Control

Our Hoe-140 is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for advanced research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality guidelines for research chemicals, ensuring reliable and reproducible performance in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Biological Activity	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.