Description

5-Bromopyridine-2-Carbonyl Chloride is a versatile and highly reactive organic building block, specifically an acid chloride derivative of a brominated pyridine. This compound is crucial for introducing the 5-bromo-2-pyridylcarbonyl moiety into target molecules, enabling the synthesis of complex amides, esters, and heterocycles. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and other small-molecule drug discovery programs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging its halogen and reactive carbonyl functionalities.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized pyridine-based ligands used in metal-catalyzed reactions and coordination chemistry.
• Material Science Research: Employed in the synthesis of functionalized polymers and organic electronic materials where the pyridine core is integral.
• Custom Synthesis and Contract Manufacturing: A critical reagent for fine chemical and CDMO (Contract Development and Manufacturing Organization) providers offering bespoke synthesis services.
• Bioconjugation and Probe Synthesis: Useful for labeling biomolecules or creating fluorescent probes and other diagnostic tools due to its reactive acid chloride group.

Basic Information

Product Name	5-Bromopyridine-2-Carbonyl Chloride
CAS No.	137178-88-2
Molecular Formula	C6H3BrClNO
Molecular Weight	220.45 g/mol
Synonyms	2-Pyridinecarbonyl chloride, 5-bromo-; 5-Bromo-2-pyridinecarbonyl chloride; 5-Bromopicolinoyl chloride; 5-Bromo-2-picolinoyl chloride; 5-Bromopyridine-2-carboxylic acid chloride; (5-Bromopyridin-2-yl)carbonyl chloride
EINECS	Contact for details

Quality Control

Our 5-Bromopyridine-2-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to handle and store the material under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis and maintain stability. Recommended storage temperature is 2-8°C for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.