Description

Foropafant is a selective platelet-activating factor (PAF) receptor antagonist, a compound of significant interest in pharmacological research. Its primary value lies in its ability to modulate inflammatory pathways, making it a crucial tool for investigating conditions related to PAF-mediated responses. This product is essential for research and development laboratories in the pharmaceutical and biotechnology sectors focused on inflammation, allergy, and cardiovascular research. Foropafant CAS NO 136468-36-5 is supplied to support high-purity chemical synthesis and advanced biological studies.

Application

• Pharmacological Research: Used as a reference standard and active agent in studies targeting the PAF receptor pathway.
• Inflammation Models: Critical for in vitro and in vivo research on inflammatory diseases, including asthma, sepsis, and anaphylaxis.
• Cardiovascular Studies: Employed to investigate the role of PAF in conditions such as shock, ischemia, and atherosclerosis.
• Drug Discovery & Development: Serves as a key intermediate or biological tool compound in the synthesis and screening of new therapeutic agents.
• Biochemical Assays: Utilized in receptor binding assays and enzyme studies to elucidate mechanism of action.
• Academic Research: Supports fundamental scientific investigations in university and institutional laboratories.

Basic Information

Product Name	Foropafant
CAS No.	136468-36-5
Molecular Formula	C27H29N3O4
Molecular Weight	459.54 g/mol
Synonyms	WEB 2347; (±)-Foropafant; 4-(2-Chlorophenyl)-9-methyl-2-[3-(4-morpholinyl)propyl]-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine; 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine, 4-(2-chlorophenyl)-9-methyl-2-[3-(4-morpholinyl)propyl]-; Foropafant (WEB 2347); WEB-2347; (±)-4-(2-Chlorophenyl)-9-methyl-2-[3-(4-morpholinyl)propyl]-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
EINECS	Contact for details

Quality Control

Our Foropafant is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (IR, NMR). A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.