Description

2-Chloro-6-Ethoxypyrazine is a versatile heterocyclic building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both chloro and ethoxy substituents on the pyrazine ring, makes it a key intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the pyrazine core contributes to biological activity.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for metal-organic catalysis and coordination chemistry.
• Material Science Research: Acts as a building block for creating organic electronic materials, such as components for OLEDs or conductive polymers.
• Flavor and Fragrance Chemistry: The pyrazine moiety is explored for synthesizing complex aroma compounds, given its potential to contribute nutty, roasted notes.
• Custom Synthesis and Contract Manufacturing: Supplied to CROs and CDMOs for client-specific projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	2-Chloro-6-Ethoxypyrazine
CAS No.	136309-02-9
Molecular Formula	C6H7ClN2O
Molecular Weight	158.59 g/mol
Synonyms	6-Chloro-2-ethoxypyrazine; 2-Ethoxy-6-chloropyrazine; 6-Chloro-2-ethoxy-1,4-diazine; 2-Chloro-6-ethoxy-1,4-diazine; 2-Chloro-6-ethoxypyrazine; Ethyl 6-chloropyrazin-2-yl ether; Pyrazine, 2-chloro-6-ethoxy-
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-6-Ethoxypyrazine is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard research-grade material is characterized by HPLC, NMR, and GC-MS. A detailed Certificate of Analysis (COA) is provided with each shipment, and we support custom purity requirements for specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.