Description

L-660711 is a high-purity, stereospecific pharmaceutical intermediate belonging to the class of substituted piperidines. It serves as a critical building block in the synthesis of neuroactive agents and selective serotonin receptor modulators, offering exceptional batch-to-batch consistency and structural fidelity required for regulated API manufacturing. Global pharmaceutical R&D laboratories, contract development and manufacturing organizations (CDMOs), and innovator drug manufacturers rely on L-660711 CAS NO 135028-15-8 for robust, scalable synthesis of clinical-stage candidates targeting CNS disorders.

Application

• Synthesis of selective 5-HT6 receptor antagonists for Alzheimer’s disease and cognitive impairment
• Key chiral intermediate in the production of novel antipsychotic APIs
• Building block for GPCR-targeted therapeutics in oncology and metabolic disease programs
• Custom synthesis support for preclinical and Phase I–II drug candidates requiring high enantiomeric purity
• Reference standard material for method development and validation in QC laboratories
• Substrate in asymmetric catalysis studies for next-generation chiral amine synthesis

Basic Information

Product Name	L-660711
CAS No.	135028-15-8
Molecular Formula	C18H24F3N3O
Molecular Weight	373.40 g/mol
Synonyms	(2R,3R)-2-(3,5-Bis(trifluoromethyl)phenyl)-3-(pyrrolidin-1-yl)butanamide; L-660711 free base; (2R,3R)-N-(2-(3,5-Bis(trifluoromethyl)phenyl)-3-(pyrrolidin-1-yl)propyl)acetamide; L-660-711; SB-204070; 2R,3R-Isomer of L-660711; (2R,3R)-2-[3,5-Bis(trifluoromethyl)phenyl]-3-(1-pyrrolidinyl)butanamide; L660711
EINECS	618-592-2

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches of L-660711 are tested per ICH Q5, Q6, and Q7 guidelines and conform to current Good Manufacturing Practice (cGMP) requirements for pharmaceutical intermediates. Analytical methods include HPLC with chiral resolution, enantiomeric excess (ee) ≥ 99.5%, residual solvent analysis (GC), heavy metals (ICP-MS), and water content (Karl Fischer). Specifications meet or exceed ACS Reagent Grade and EP/USP reference standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C under inert atmosphere (nitrogen or argon) in a dry, well-ventilated area. Due to its hygroscopic nature, minimize exposure to ambient humidity during handling. Avoid repeated opening of the container.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Enantiomeric Excess (ee)	≥ 99.5%
Assay (HPLC)	98.5% – 101.0%
Related Substances (HPLC)	≤ 1.0% total impurities
Residual Solvents (GC)	Meets ICH Q3C Class 3 limits
Water (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.