Description

Mpeg-Sh CAS NO 134874-49-0 is a specialized functionalized polyethylene glycol derivative, characterized by a terminal thiol (-SH) group. This compound is a critical building block in bioconjugation and polymer chemistry, enabling the creation of stable, biocompatible linkages. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require precise and reliable PEGylation agents for drug delivery systems, surface modification, and hydrogel synthesis.

Application

• Bioconjugation and PEGylation: Used to attach polyethylene glycol (PEG) chains to therapeutic proteins, peptides, and antibodies to enhance solubility, reduce immunogenicity, and prolong circulation half-life.
• Surface Functionalization: Employed to modify the surface of nanoparticles, quantum dots, and medical devices with a hydrophilic, bio-inert PEG layer to improve biocompatibility and reduce non-specific binding.
• Crosslinking Agent: Serves as a key component in the synthesis of hydrogels and polymer networks via thiol-ene or thiol-maleimide "click" chemistry reactions for tissue engineering and controlled release applications.
• Linker Chemistry: Acts as a heterobifunctional linker to connect different molecules, such as drugs to targeting ligands or fluorescent dyes to biomolecules, through its reactive thiol terminus.
• Research & Development: A vital reagent in academic and industrial R&D for exploring novel drug delivery platforms, diagnostic probes, and smart biomaterials.

Basic Information

Product Name	Mpeg-Sh
CAS No.	134874-49-0
Molecular Formula	CnH2n+2OmS (Variable based on PEG chain length)
Molecular Weight	Variable (Typically 350 - 5000 g/mol). Contact for details.
Synonyms	α-Methoxy-ω-mercapto poly(ethylene glycol); mPEG-Thiol; Methoxy PEG Thiol; Poly(ethylene glycol) methyl ether thiol; PEG-SH; Thiolated mPEG; HS-PEG-OMe; O-(2-Mercaptoethyl) O'-methylpolyethylene Glycol
EINECS	Contact for details.

Quality Control

Our Mpeg-Sh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, consistent molecular weight, and functional group integrity. Specifications typically include assessment of thiol content, PEG chain length distribution, and levels of common impurities. Certificates of Analysis (COA) detailing purity (by NMR, HPLC), molecular weight (by GPC), and functional assay are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label. This product is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures will lead to degradation and loss of thiol activity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Assay (Thiol Content)	≥ 95% (by titration or Ellman's assay)
Purity (HPLC)	≥ 98.0%
Molecular Weight (GPC)	As per ordered grade (e.g., 2000 Da ± 5%)
Polydispersity Index (PDI)	≤ 1.05
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.