Description

2-Azabicyclo[3.1.0]Hexane-1-Carboxylicacid,Propylester,(1R)-(9Ci) is a high-purity, chiral bicyclic proline derivative that serves as a critical building block in advanced organic synthesis. Its unique constrained structure and defined stereochemistry make it an invaluable intermediate for constructing complex molecules with high biological relevance. This compound is primarily sought after by pharmaceutical R&D and fine chemical manufacturers for the development of novel active pharmaceutical ingredients (APIs), peptidomimetics, and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, antiviral agents, and other therapeutic compounds.
• Peptidomimetics & Constrained Amino Acids: Used to introduce rigid, bicyclic proline analogs into peptide backbones to enhance metabolic stability and receptor selectivity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the synthesis of novel chiral ligands and organocatalysts.
• Agrochemical Research: Employed in the development of novel, biologically active molecules for crop protection.
• Academic & Discovery Chemistry: A valuable tool for medicinal chemists exploring new chemical space and structure-activity relationships (SAR).
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific advanced intermediates under cGMP conditions where required.

Basic Information

Item	Details
Product Name	2-Azabicyclo[3.1.0]Hexane-1-Carboxylicacid,Propylester,(1R)-(9Ci)
CAS No.	134732-57-3
Molecular Formula	C9H15NO2
Molecular Weight	169.22 g/mol
Synonyms	(1R)-1-(Propoxycarbonyl)-2-azabicyclo[3.1.0]hexane; (1R)-2-Azabicyclo[3.1.0]hexane-1-carboxylic acid propyl ester; Propyl (1R)-2-azabicyclo[3.1.0]hexane-1-carboxylate; (1R)-1-Propoxycarbonyl-2-azabicyclo[3.1.0]hexane; (R)-Propyl 2-azabicyclo[3.1.0]hexane-1-carboxylate; Bicyclic Proline Ester; (1R,5S)-2-Azabicyclo[3.1.0]hexane-1-carboxylic acid propyl ester
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for this advanced intermediate. Production and analysis are conducted in facilities adhering to ISO 9001 quality management standards. Every batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles, typically determined by HPLC, GC, and chiral HPLC methods. Our commitment ensures reliable batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.